Article
At the next stop sign turn right: the metalloprotease Tolloid-related 1 controls defasciculation of motor axons in Drosophila.
Development (Cambridge, England) - 1 Oct 2006
Meyer Frauke, Aberle Hermann
Abstract excerpt
Navigation of motoneuronal growth cones toward the somatic musculature in Drosophila serves as a model system to unravel the molecular mechanisms of axon guidance and target selection. In a large-scale mutagenesis screen, we identified piranha, a motor axon guidance mutant that shows strong defects in the neuromuscular connectivity pattern. In piranha mutant embryos, permanent defasciculation errors occur at...
Topics
- Animals
- Axons
- Bone Morphogenetic Protein 1
- Chromosome Mapping
- Cloning, Molecular
- Disintegrins
- Drosophila
- Drosophila Proteins
- Embryo, Nonmammalian
- Metalloendopeptidases
- Motor Neurons
- Muscles
- Mutation
- Neuromuscular Junction
- Phenotype
- Tolloid-Like Metalloproteinases
- Transgenes