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Article

The polyproline site in hinge 2 influences the functional capacity of truncated dystrophins.

PLoS genetics - 20 May 2010

Banks Glen B, Judge Luke M, Allen James M, Chamberlain Jeffrey S

Abstract excerpt

Mutations in dystrophin can lead to Duchenne muscular dystrophy or the more mild form of the disease, Becker muscular dystrophy. The hinge 3 region in the rod domain of dystrophin is particularly prone to deletion mutations. In-frame deletions of hinge 3 are predicted to lead to BMD, however the severity of disease can vary considerably. Here we performed extensive structure-function analyses of truncated...

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Identifiers

PMID: 20502633
DOI: 10.1371/journal.pgen.1000958
PMCID: PMC2873924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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