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Article

Spectrin-like repeats from dystrophin and alpha-actinin-2 are not functionally interchangeable.

Human molecular genetics - 1 Aug 2002

Harper Scott Q, Crawford Robert W, DelloRusso Christiana, Chamberlain Jeffrey S

Abstract excerpt

Mutations in the dystrophin gene result in Duchenne muscular dystrophy (DMD). Dystrophin is a multidomain protein that functions to stabilize the sarcolemmal membrane during muscle contraction. The central rod domain has been proposed to act as a shock absorber, as a force transducer or as a spacer separating important N- and C-terminal domains that interact with actin and the dystrophin-glycoprotein complex...

Read the complete abstract on PubMed

Topics

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Share to Actinin
Share to Dystrophin
Share to Mice, Inbred mdx

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Contraction

Share to Muscular Dystrophy, Animal

Share to Muscular Dystrophy, Duchenne

Share to Repetitive Sequences, Amino Acid

Share to Spectrin

Source

Identifiers

PMID: 12140183
DOI: 10.1093/hmg/11.16.1807

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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