Article
Fine definition of the CXCR4-binding region on the V3 loop of feline immunodeficiency virus surface glycoprotein.
PloS one - 18 May 2010
Hu Qiong-Ying, Fink Elizabeth, Hong Yang, Wang Cathy, Grant Chris K, Elder John H
Abstract excerpt
The chemokine receptor CXCR4 is shared by primary and laboratory-adapted strains of feline immunodeficiency virus (FIV) for viral entry. Our previous studies implicated a contiguous nine-amino-acid region of the V3 loop of the FIV envelope surface as important in CXCR4 binding and virus entry. The binding is specific for CXCR4 since it can be inhibited by AMD3100, a selective CXCR4 inhibitor. Additional...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
