Article
Searching for signaling balance through the identification of genetic interactors of the Rab guanine-nucleotide dissociation inhibitor gdi-1.
PloS one - 13 May 2010
Lee Anna Y, Perreault Richard, Harel Sharon, Boulier Elodie L, Suderman Matthew, Hallett Michael, Jenna Sarah
Abstract excerpt
BACKGROUND: The symptoms of numerous diseases result from genetic mutations that disrupt the homeostasis maintained by the appropriate integration of signaling gene activities. The relationships between signaling genes suggest avenues through which homeostasis can be restored and disease symptoms subsequently reduced. Specifically, disease symptoms caused by loss-of-function mutations in a particular gene may be...
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