Article
Secondary integrase resistance mutations found in HIV-1 minority quasispecies in integrase therapy-naive patients have little or no effect on susceptibility to integrase inhibitors.
Antimicrobial agents and chemotherapy - 1 Sept 2010
Ceccherini-Silberstein Francesca, Van Baelen Kurt, Armenia Daniele, Trignetti Maria, Rondelez Evelien, Fabeni Lavinia, Scopelliti Fernanda, Pollicita Michela, Van Wesenbeeck Liesbeth, Van Eygen Veerle, Dori Luca, Sarmati Loredana, Aquaro Stefano, Palamara Guido, Andreoni Massimo, Stuyver Lieven J, Perno Carlo Federico
Abstract excerpt
The goal of this study was to explore the presence of integrase strand transfer inhibitor (InSTI) resistance mutations in HIV-1 quasispecies present in InSTI-naïve patients and to evaluate their in vitro effects on phenotypic susceptibility to InSTIs and their replication capacities. The RT-RNase H-IN region was PCR amplified from plasma viral RNA obtained from 49 HIV-1 subtype B-infected patients (21 drug naïve...
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