Article
The p53 tumour suppressor gene.
Nature - 6 Jun 1991
Levine A J, Momand J, Finlay C A
Abstract excerpt
The cell cycle is composed of a series of steps which can be negatively or positively regulated by various factors. Chief among the negative regulators is the p53 protein. Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of DNA tumour viruses, can lead...
Topics
- Cell Cycle
- Cell Division
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Genes, p53
- Humans
- Mutation
- Neoplasms
- Neoplastic Syndromes, Hereditary
- Oncogenes
- Oncogenic Viruses