Article
The p53 Tumor-Suppressor Gene
14 May 1992
Abstract excerpt
OVER the past 15 years an examination of cancerous tissues has led to the identification of alterations in a number of genes that regulate cell growth and proliferation.1 These mutations have been identified in two distinct categories of genes, oncogenes and tumor-suppressor genes. Typically, mutations in oncogenes occur in one of the two alleles of the gene, and they act in a fashion dominant to the wild-type...
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