Article
Common gating of both CLC transporter subunits underlies voltage-dependent activation of the 2Cl-/1H+ exchanger ClC-7/Ostm1.
The Journal of biological chemistry - 4 Oct 2013
Ludwig Carmen F, Ullrich Florian, Leisle Lilia, Stauber Tobias, Jentsch Thomas J
Abstract excerpt
CLC anion transporters form dimers that function either as Cl(-) channels or as electrogenic Cl(-)/H(+) exchangers. CLC channels display two different types of "gates," "protopore" gates that open and close the two pores of a CLC dimer independently of each other and common gates that act on both pores simultaneously. ClC-7/Ostm1 is a lysosomal 2Cl(-)/1H(+) exchanger that is slowly activated by depolarization....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.