Article
[Prevalence of Val158Met polymorphism in COMT gene on non-BRCA1/2 hereditary breast cancer].
Zhonghua wai ke za zhi [Chinese journal of surgery] - 1 Oct 2006
Song Chuan-gui, Hu Zhen, Yuan Wen-tao, Di Gen-hong, Shen Zhen-zhou, Huang Wei, Shao Zhi-min
Abstract excerpt
OBJECTIVE: To explore the prevalence of Val158Met polymorphism in Catechol-O-methyltransferase (COMT) gene and its effect on genetic susceptibility for breast cancer in Shanghai population. METHODS: A total of 114 patients with BRCA1/BRCA 2 negative hereditary breast cancer from independent families and 121 age-matched healthy controls were analyzed. Genotype analysis was conducted by polymerase chain reaction...
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