Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Perifosine selectively induces cell cycle block and modulates retinoblastoma and E2F1 protein levels in p53 mutated leukemic cell lines.

Investigational new drugs - 1 Apr 2011

Celeghini Claudio, Voltan Rebecca, Rimondi Erika, Gattei Valter, Zauli Giorgio

Abstract excerpt

The effect of the single-chain alkylphospholipid perifosine was analyzed in p53(wild-type) (SKW6.4, OCI and MOLM), p53(mutated) (BJAB, MAVER) and p53(null) (HL-60) leukemic cell lines. Perifosine promoted cytotoxicity with a combination of apoptosis induction in all cell lines and cell cycle bloc...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Survival
Share to Drug Screening Assays, Antitumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to E2F1 Transcription Factor

Share to Leukemia

Share to Phosphorylcholine

Share to Retinoblastoma Protein

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 20130960
DOI: 10.1007/s10637-009-9370-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20130960-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Perifosine selectively induces cell cycle block and modulates retinoblastoma and E2F1 protein levels in p53 mutated leukemic cell lines.PMID 20130960Read ↗

Transcriptional Activation of p21waf1/cip1 by AlkylphospholipidsSemantic proximity Read ↗

Genome-wide identification of genetic determinants for the cytotoxicity of perifosine.Semantic proximity Read ↗

In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine.Semantic proximity Read ↗

Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation.Semantic proximity Read ↗

Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-κB signaling pathway in a human breast cancer cell lineSemantic proximity Read ↗

Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53.Semantic proximity Read ↗

Recent Advances in the Therapeutic Perspectives of Nutlin-3Semantic proximity Read ↗

Cyclophosphamide chemotherapy induces early p53-directed cytotoxic gene expression changes in ovarian gonadotoxicitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.