Article
MCP-1 and MIP-1A gene polymorphisms in Japanese patients with sarcoidosis.
Internal medicine (Tokyo, Japan) - 1 Oct 2002
Takada Toshinori, Suzuki Eiichi, Morohashi Kazuaki, Omori Kentaro, Gejyo Fumitake
Abstract excerpt
OBJECTIVES: Monocyte chemoattractant protein (MCP)-1 and macrophage inflammatory protein (MIP)-1alpha exhibit chemotactic activity toward macrophages/monocytes and induce the production of inflammatory cytokines affecting granuloma formation. Recently, a single nucleotide polymorphism (SNP) in the MCP-1 distal regulatory region and a dinucleotide repeat in the MIP-1A gene promoter region were identified. We...
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