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Article

Splicing Diversity of the Human <i>OCLN</i> Gene and Its Biological Significance for Hepatitis C Virus Entry

13 May 2010

Abstract excerpt

Persistent hepatitis C virus (HCV) infection is a primary etiological factor for the development of chronic liver disease, including cirrhosis and cancer. A recent study identified occludin (OCLN), an integral tight junction protein, as one of the key factors for HCV entry into cells. We explored the splicing diversity of OCLN in normal human liver and observed variable expression of alternative splice variants,...

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PMID: 20463075
DOI: 10.1128/jvi.00196-10

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