Article
Increased amplification success from forensic samples with locked nucleic acids.
Forensic science international. Genetics - 1 Aug 2011
Ballantyne Kaye N, van Oorschot Roland A H, Mitchell R John
Abstract excerpt
Inadequate sample quantities and qualities can commonly result in poor DNA amplification success rates for forensic case samples. In some instances, modifying the PCR protocol or components may assist profiling by overcoming inhibition, or reducing the threshold required for successful amplification and detection. Incorporation of locked nucleic acids (LNAs) into PCR primers has previously been shown to increase...
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