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Modeling Keratoconus Using Induced Pluripotent Stem Cells

12 Jul 2016

Abstract excerpt

PURPOSE: To model keratoconus (KC) using induced pluripotent stem cells (iPSC) generated from fibroblasts of both KC and normal human corneal stroma by a viral method. METHODS: Both normal and KC corneal fibroblasts from four human donors were reprogramed directly by delivering reprogramming factors in a single virus using 2A "self-cleaving" peptides, using a single polycistronic lentiviral vector coexpressing...

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Share to Corneal surgery and disorders
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PMID: 27403997
DOI: 10.1167/iovs.16-19105

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