Autoimmunity in patients with resistance to thyroid hormone.

doi:10.1210/jc.2009-2179

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Article

Autoimmunity in patients with resistance to thyroid hormone.

The Journal of clinical endocrinology and metabolism - 1 Jul 2010

Barkoff Marla S, Kocherginsky Masha, Anselmo João, Weiss Roy E, Refetoff Samuel

Abstract excerpt

CONTEXT: Resistance to thyroid hormone (RTH) is an inherited syndrome most often caused by thyroid hormone receptor beta (TRbeta) gene mutations. Given that autoimmune thyroid disease (AITD) is prevalent in the general population, its coexistence with RTH has been presumed coincidental. It was recently proposed that chronic TSH stimulation in RTH may induce an autoimmune response, thereby increasing the chance of...

Topics

Autoantibodies
Autoimmunity
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Odds Ratio
Regression Analysis
Thyroid Hormone Receptors beta
Thyroid Hormone Resistance Syndrome
Thyroid Hormones

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Identifiers

PMID: 20444926
DOI: 10.1210/jc.2009-2179
PMCID: PMC2928894

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