Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses.

Journal of virology - 1 Sept 2017

Clark Amelia M, Nogales Aitor, Martinez-Sobrido Luis, Topham David J, DeDiego Marta L

Abstract excerpt

In 2009, a novel H1N1 influenza virus emerged in humans, causing a global pandemic. It was previously shown that the NS1 protein from this human 2009 pandemic H1N1 (pH1N1) virus was an effective interferon (IFN) antagonist but could not inhibit general host gene expression, unlike other NS1 proteins from seasonal human H1N1 and H3N2 viruses. Here we show that the NS1 protein from currently circulating pH1N1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Viral
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Host-Pathogen Interactions

Share to Immunity, Innate

Share to Influenza A Virus, H1N1 Subtype

Share to Orthomyxoviridae Infections

Share to Viral Nonstructural Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 28637754
DOI: 10.1128/JVI.00721-17
PMCID: PMC5553169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses.PMID 28637754Read ↗

Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in HumansSemantic proximity Read ↗

Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein.Semantic proximity Read ↗

NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A VirusesSemantic proximity Read ↗

Dual R108K and G189D Mutations in the NS1 Protein of A/H1N1 Influenza Virus Counteract Host Innate Immune Responses.Semantic proximity Read ↗

NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses.Semantic proximity Read ↗

Enhanced genome replication activity of pandemic H1N1 influenza A virus through PA mutations.Semantic proximity Read ↗

The C-terminus of non-structural protein 1 (NS1) in H5N8 clade 2.3.4.4 avian influenza virus affects virus fitness in human cells and virulence in miceSemantic proximity Read ↗

The NS1 Protein of the 1918 Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism PathwaysSemantic proximity Read ↗

Evolution of the Hemagglutinin Protein of the New Pandemic H1N1 Influenza Virus: Maintaining Optimal Receptor Binding by Compensatory SubstitutionsSemantic proximity Read ↗

2009 Pandemic H1N1 Influenza Virus Causes Disease and Upregulation of Genes Related to Inflammatory and Immune Responses, Cell Death, and Lipid Metabolism in PigsSemantic proximity Read ↗

Evolution and dynamics of the pandemic H1N1 influenza hemagglutinin protein from 2009 to 2017.Semantic proximity Read ↗

A Closer Look at the NS1 of Influenza VirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.