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Article

Population pharmacokinetics of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine®) in cancer patients.

Cancer chemotherapy and pharmacology - 1 Feb 2011

Kolesar Jill, Brundage Richard C, Pomplun Marcia, Alberti Dona, Holen Kyle, Traynor Anne, Ivy Percy, Wilding George

Abstract excerpt

PURPOSE: The purpose of this study was to develop a population pharmacokinetic (PK) model for 3-AP, to evaluate the effect of ABCB1 polymorphisms on the pharmacokinetic profile of 3-AP, and to assess the relationship between 3AP disposition and patient covariates. METHODS: A total of 40 patients with advanced cancer from two phase 1 studies were included in the population PK model building. Patients received 3-AP...

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Identifiers

PMID: 20440618
DOI: 10.1007/s00280-010-1331-z
PMCID: PMC3059107

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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