Article
Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C.
Gastroenterology - 1 Jul 2011
Honda Masao, Takehana Kenji, Sakai Akito, Tagata Yusuke, Shirasaki Takayoshi, Nishitani Shinobu, Muramatsu Takahiko, Yamashita Tatsuya, Nakamoto Yasunari, Mizukoshi Eishiro, Sakai Yoshio, Yamashita Taro, Nakamura Mikiko, Shimakami Tetsuro, Yi Minkyung, Lemon Stanley M, Suzuki Tetsuo, Wakita Takaji, Kaneko Shuichi
Abstract excerpt
BACKGROUND & AIMS: Patients with advanced chronic hepatitis C (CH-C) often are malnourished, but the effects of malnutrition on interferon (IFN) signaling and response to treatment have not been determined. We assessed the importance of the nutritional state of the liver on IFN signaling and treatment response. METHODS: We studied data from 168 patients with CH-C who were treated with the combination of...
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