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Article

Targeting ALDH2 with disulfiram/copper reverses the resistance of cancer cells to microtubule inhibitors

20 Nov 2017

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29155365
DOI: 10.1016/j.yexcr.2017.11.004

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Targeting ALDH2 with disulfiram/copper reverses the resistance of cancer cells to microtubule inhibitorsPMID 29155365Read ↗

Disulfiram/copper induces antitumor activity against gastric cancer cells in vitro and in vivo by inhibiting S6K1 and c-MycSemantic proximity Read ↗

Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cellsSemantic proximity Read ↗

Disulfiram’s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenaseSemantic proximity Read ↗

Copper: An Intracellular Achilles’ Heel Allowing the Targeting of Epigenetics, Kinase Pathways, and Cell Metabolism in Cancer TherapeuticsSemantic proximity Read ↗

Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapiesSemantic proximity Read ↗

Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cellsSemantic proximity Read ↗

Disulfiram targets cancer stem-like properties and the HER2/Akt signaling pathway in HER2-positive breast cancer.Semantic proximity Read ↗

Disulfiram treatment facilitates phosphoinositide 3-kinase inhibition in human breast cancer cells in vitro and in vivo.Semantic proximity Read ↗

Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44+ human breast cancer cellsSemantic proximity Read ↗

Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activitySemantic proximity Read ↗

High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: Interaction with IQ motif-containing factorsSemantic proximity Read ↗

Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex<i>in vitro</i>and<i>in vivo</i>in patient-derived xenograft modelsSemantic proximity Read ↗

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