Article
Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands.
The Journal of biological chemistry - 25 Jun 2010
Shridas Preetha, Bailey William M, Boyanovsky Boris B, Oslund Rob C, Gelb Michael H, Webb Nancy R
Abstract excerpt
We developed C57BL/6 mice with targeted deletion of group X secretory phospholipase A(2) (GX KO). These mice have approximately 80% higher plasma corticosterone concentrations compared with wild-type (WT) mice under both basal and adrenocorticotropic hormone (ACTH)-induced stress conditions. This increased corticosterone level was not associated with increased circulating ACTH or a defect in the...
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