Article
Growth Restriction and Genomic Imprinting-Overlapping Phenotypes Support the Concept of an Imprinting Network.
Genes - 17 Apr 2021
Eggermann Thomas, Davies Justin H, Tauber Maithé, van den Akker Erica, Hokken-Koelega Anita, Johansson Gudmundur, Netchine Irène
Abstract excerpt
Intrauterine and postnatal growth disturbances are major clinical features of imprinting disorders, a molecularly defined group of congenital syndromes caused by molecular alterations affecting parentally imprinted genes. These genes are expressed monoallelically and in a parent-of-origin manner, and they have an impact on human growth and development. In fact, several genes with an exclusive expression from the...
Topics
- DNA Methylation
- Female
- Fetal Growth Retardation
- Gene Regulatory Networks
- Genetic Predisposition to Disease
- Genomic Imprinting
- Humans
- Phenotype
- Precision Medicine
- Pregnancy