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Article

Conformation sensors that distinguish monomeric proteins from oligomers in live cells.

Chemistry & biology - 23 Apr 2010

Ramdzan Yasmin M, Nisbet Rebecca M, Miller Jason, Finkbeiner Steven, Hill Andrew F, Hatters Danny M

Abstract excerpt

Proteins prone to misfolding form large macroscopic deposits in many neurodegenerative diseases. Yet the in situ aggregation kinetics remains poorly understood because of an inability to demarcate precursor oligomers from monomers. We developed a strategy for mapping the localization of soluble oligomers and monomers directly in live cells. Sensors for mutant huntingtin, which forms aggregates in Huntington's...

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Identifiers

PMID: 20416508
DOI: 10.1016/j.chembiol.2010.03.011
PMCID: PMC3564667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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