Article
Inhibition of septation in Bacillus subtilis by a peptide antibiotic, edeine B(1).
Biological & pharmaceutical bulletin - 1 Jan 2010
Shimotohno Kumiko W, Kawamura Fujio, Natori Yousuke, Nanamiya Hideaki, Magae Junji, Ogata Hiromitsu, Endo Toyoshige, Suzuki Takeshi, Yamaki Hiroshi
Abstract excerpt
A peptide antibiotic, edeine B(1), exerts a lethal action in Bacillus subtilis causing filamentous morphology. This antibiotic assumes to inhibit cell division by interacting with FtsZ and inhibiting FtsZ polymerization. The temperature-sensitive mutant ftsZ ts1 was shown to be hypersensitive to the antibiotic as compared to the parent 168 with respect to its lethal action and the sensitivity to the antibiotic of...
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