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Article

Learning discloses abnormal structural and functional plasticity at hippocampal synapses in the APP23 mouse model of Alzheimer's disease.

Learning & memory (Cold Spring Harbor, N.Y.) - 1 May 2010

Middei Silvia, Roberto Anna, Berretta Nicola, Panico Maria Beatrice, Lista Simone, Bernardi Giorgio, Mercuri Nicola B, Ammassari-Teule Martine, Nisticò Robert

Abstract excerpt

B6-Tg/Thy1APP23Sdz (APP23) mutant mice exhibit neurohistological hallmarks of Alzheimer's disease but show intact basal hippocampal neurotransmission and synaptic plasticity. Here, we examine whether spatial learning differently modifies the structural and electrophysiological properties of hippocampal synapses in APP23 and wild-type mice. While no genotypic difference was found in the pseudotrained mice,...

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Identifiers

PMID: 20404004
DOI: 10.1101/lm.1748310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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