Article
Functional variation in the arginine vasopressin 2 receptor as a modifier of human plasma von Willebrand factor levels.
Journal of thrombosis and haemostasis : JTH - 1 Jul 2010
Nossent A Y, Robben J H, Deen P M T, Vos H L, Rosendaal F R, Doggen C J M, Hansen J L, Sheikh S P, Bertina R M, Eikenboom J C J
Abstract excerpt
SUMMARY OBJECTIVES: Stimulation of arginine vasopressin 2 receptor (V2R) with arginine vasopressin (AVP) results in a rise in von Willebrand factor (VWF) and factor VIII plasma levels. We hypothesized that gain-of-function variations in the V2R gene (AVPR2) would lead to higher plasma levels of V...
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