Vasopressin receptor mutations and nephrogenic diabetes insipidus.

doi:10.1016/s0188-4409(99)00063-6

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Article

Vasopressin receptor mutations and nephrogenic diabetes insipidus.

Archives of medical research - 1 Jan 2000

Birnbaumer M

Abstract excerpt

X-linked recessive nephrogenic diabetes insipidus is caused by mutations in the gene encoding the V2 vasopressin receptor (V2R), the mediator of the antidiuretic effect of arginine vasopressin (AVP) in mammalian kidneys. Upon binding to AVP, the receptor activates the G protein Gs, stimulating a phosphorylation cascade that promotes translocation of presynthesized water channels to the apical surface of the...

Topics

Amino Acid Sequence
Animals
Arginine Vasopressin
Diabetes Insipidus, Nephrogenic
Humans
Incidence
Molecular Sequence Data
Mutation
Receptors, Vasopressin

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PMID: 10714359
DOI: 10.1016/s0188-4409(99)00063-6

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