Type I restriction-modification loci reveal high allelic diversity in clinical Helicobacter pylori isolates.

Abstract excerpt

BACKGROUND: A remarkable variety of restriction-modification (R-M) systems is found in Helicobacter pylori. Since they encompass a large portion of the strain-specific H. pylori genes and therefore contribute to genetic variability, they are suggested to have an impact on disease outcome. Type I R-M systems comprise three different subunits and are the most complex of the three types of R-M systems. AIMS: We...

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