Article
Expression of N-myc and c-src protooncogenes correlating to the undifferentiated phenotype and prognosis of primary neuroblastomas.
Cancer research - 15 Jun 1991
Matsunaga T, Takahashi H, Ohnuma N, Tanabe M, Yoshida H, Iwai J, Shirasawa H, Simizu B
Abstract excerpt
Genomic amplification of the N-myc protooncogene in neuroblastomas correctly predicts poor outcome for the patients. However, the prognosis for neuroblastomas with a single copy of N-myc is also poor in cases diagnosed after 1 year of age but good in infantile cases. To elucidate the different prognoses depending upon the age of the patients with neuroblastoma, we performed an analysis of the expression of...
Topics
- Blotting, Northern
- Blotting, Southern
- Cell Line
- Child
- Child, Preschool
- DNA, Neoplasm
- Female
- Gene Amplification
- Gene Expression
- Genes, myc
- Genes, src