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Article

Survivin mRNA Levels Are Associated With Biology of Disease and Patient Survival in Neuroblastoma: A Report From the Children's Oncology Group

1 Jul 2006

Abstract excerpt

Alterations in apoptotic mechanisms favoring cell survival may be vital for modifying tumor behavior. Survivin, an inhibitor of apoptosis, and caspase 8, a proapoptotic enzyme, are key players in cellular apoptotic mechanisms. We investigated whether the levels of survivin and caspase 8 and the ratio between these 2 apoptotic factors correlate with tumor biology and predicts outcome in patients with...

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Identifiers

PMID: 16825985
DOI: 10.1097/01.mph.0000212937.00287.e5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Survivin mRNA Levels Are Associated With Biology of Disease and Patient Survival in Neuroblastoma: A Report From the Children's Oncology GroupPMID 16825985Read ↗

Anti-apoptosis gene, survivin, and prognosis of neuroblastomaSemantic proximity Read ↗

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Loss of Caspase-8 Expression Does Not Correlate with MYCN Amplification, Aggressive Disease, or Prognosis in NeuroblastomaSemantic proximity Read ↗

Survivin, Survivin-2B, and Survivin-deItaEx3 expression in medulloblastoma: biologic markers of tumour morphology and clinical outcomeSemantic proximity Read ↗

High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastomaSemantic proximity Read ↗

Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions.Semantic proximity Read ↗

Investigations of survivin: the past, present and futureSemantic proximity Read ↗

Caspase 8L, a novel inhibitory isoform of caspase 8, is associated with undifferentiated neuroblastoma.Semantic proximity Read ↗

Survivin: Role in Normal Cells and in Pathological ConditionsSemantic proximity Read ↗

Subtype of Neuroblastoma Cells with High KIT Expression Are Dependent on KIT and Its Knockdown Induces Compensatory Activation of Pro-Survival SignalingSemantic proximity Read ↗

Comprehensive genetic and histopathologic study reveals three types of neuroblastoma tumors.Semantic proximity Read ↗

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