Article
Cetuximab, its clinical use and future perspectives.
Anti-cancer drugs - 1 Feb 2008
Rivera Fernando, Vega-Villegas Maria Eugenia, López-Brea Marta Francisca
Abstract excerpt
Increase in the expression of epidermal growth factor receptors (EGFRs) has been observed in many tumours. EGFR overexpression usually correlates with a more advanced stage of the disease, a poorer prognosis and a worse chemotherapy response. For all the aforementioned reasons, EGFR inhibition can be considered an attractive approach in cancer treatment. One strategy has been extracellular domain receptor...
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