Implication of genetic variants in overweight and obesity susceptibility among the young Arab population of the United Arab Emirates.

doi:10.1016/j.gene.2020.144509

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Article

Implication of genetic variants in overweight and obesity susceptibility among the young Arab population of the United Arab Emirates.

Gene - 20 May 2020

El Hajj Chehadeh Sarah, Osman Wael, Nazar Suna, Jerman Laila, Alghafri Ameera, Sajwani Ali, Alawlaqi Mohamed, AlObeidli Mohamed, Jelinek Herbert F, AlAnouti Fatme, Khalaf Kinda, Alsafar Habiba

Abstract excerpt

OBJECTIVE: Overweight and obesity are major risk factors for Type 2 Diabetes Mellitus (T2DM), cardiovascular disease (CVD) and cancer. Genetic predisposition has been shown to play a key role in obesity, and genome-wide association studies (GWAS) have identified multiple loci linked with obesity in various ethnic groups. The aim of this study was to validate the reported genetic variants associated with obesity...

Topics

Adolescent
Adult
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Diabetes Mellitus, Type 2
Female
Genetic Loci
Genetic Predisposition to Disease
Genetics, Population
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Membrane Proteins

Obesity

Overweight

Polymorphism, Single Nucleotide

Risk

Sex Factors

United Arab Emirates

Source

Open in PubMed

Identifiers

PMID: 32109558
DOI: 10.1016/j.gene.2020.144509

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