Article

Regulatory network controlling tumor-promoting inflammation in human cancers

2018-06-20

Abstract excerpt

<h4>ABSTRACT</h4> Using an inducible, inflammatory model of breast cellular transformation, we describe the transcriptional regulatory network mediated by STAT3, NF-κB, and AP-1 factors on a genomic scale. These regulators form transcriptional complexes that directly regulate the expression of hundreds of genes in oncogenic pathways via a positive feedback loop. This inflammatory feedback loop, which functions to...

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Literature Corpus work: 723bc0d0-71ca-5b0d-98ba-a9c7096b5402
DOI: 10.1101/352062

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