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Article

[The RET gene and medullary thyroid cancer: from mutations to the planning of therapy].

Chirurgia italiana - 1 Jan 2000

Conzo Giovanni, Ruggiero Roberto, Palazzo Antonietta, Della Pietra Cristina, Stanzione Francesco, Livrea Antonio, Docimo Giovanni

Abstract excerpt

The RET gene codes for a tyrosine kinase receptor, expressed in neural crest derived cells playing a central role during embryogenesis. The RET proto-oncogene is responsible for medullary thyroid cancer and multiple endocrine neoplasia type 2. To date, more than 50 germline point mutations have been described. A specific correlation between genotype and phenotype is well recognized. Genetic testing is predictive...

Topics

Carcinoma, Medullary
Humans
Mutation
Proto-Oncogene Mas
Proto-Oncogene Proteins c-ret
Thyroid Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20380254

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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