Article
Genetic polymorphisms in GSTA1, GSTP1, GSTT1, and GSTM1 and gastric cancer risk in a Vietnamese population.
Oncology research - 1 Jan 2010
Nguyen Thai V, Janssen Marcel J R, van Oijen Martijn G H, Bergevoet Saskia M, te Morsche Rene H M, van Asten Henri, Laheij Robert J F, Peters Wilbert H M, Jansent Jan B M J
Abstract excerpt
Glutathione S-transferases (GSTs) are a family of enzymes involved in the detoxification of noxious agents. Genes encoding for GSTA1, GSTP1, GSTT1, and GSTM1 proteins are polymorphic in humans, which can result in (partial) loss of enzyme activity. Previous epidemiologic studies have associated dysfunction of these GST genes with a higher risk of cancer, but this is still controversial. The aim of this study was...
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