Article
Gastric carcinogenesis: Possible role of polymorphisms of GSTM1, GSTT1, and GSTP1 genes.
Scandinavian journal of gastroenterology - 1 Jan 2008
Tripathi Shweta, Ghoshal Ujjala, Ghoshal Uday C, Mittal Balraj, Krishnani Narendra, Chourasia Dipti, Agarwal Ashok K, Singh Kartar
Abstract excerpt
OBJECTIVE: Although Helicobacter pylori infection is associated with gastric cancer (GC), only 1% of patients develop a malignancy, which suggests a role of host genetic factors. The aim of this study was to investigate the role of polymorphisms of GSTM1, GSTT1, and GSTP1 genes, which encode for carcinogen-detoxifying enzymes, in gastric mutagenesis. MATERIAL AND METHODS: Genotyping of GSTT1 and GSTM1 was done...
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