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Exploring the concordance ofAspergillus fumigatuspathogenicity in mice andToll-deficient flies

7 Apr 2010

Abstract excerpt

The pathogenicity of six mutants of Aspergillus fumigatus that had been previously characterized in mice was assessed in Toll-deficient Drosophila melanogaster flies. Four out of six mutants of A. fumigatus, which displayed attenuated virulence in mice due to defects in siderophore biosynthesis (DeltasidA, DeltasidD), PABA metabolism (H515), and starvation stress response (DeltacpcA), also had attenuated...

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PMID: 20370364
DOI: 10.3109/13693780903225813

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