Article
The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission.
Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2010
Gilmore Robert D, Howison Rebekah R, Dietrich Gabrielle, Patton Toni G, Clifton Dawn R, Carroll James A
Abstract excerpt
The spirochetal agent of Lyme disease, Borrelia burgdorferi, is transmitted by bites of Ixodes ticks to mammalian reservoir hosts and humans. The mechanism(s) by which the organism is trafficked from vector to host is poorly understood. In this study, we demonstrate that a B. burgdorferi mutant strain deficient in the synthesis of the bba64 gene product was incapable of infecting mice via tick bite even though...
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