Article
Mutations in the cardiac transcription factor GATA4 in patients with lone atrial fibrillation.
European journal of medical genetics - 1 Jan 2000
Posch Maximilian G, Boldt Leif-Hendrik, Polotzki Michael, Richter Silke, Rolf Sascha, Perrot Andreas, Dietz Rainer, Ozcelik Cemil, Haverkamp Wilhelm
Abstract excerpt
Familial recurrence of atrial fibrillation (AF) is reported in up to 15% of patients with lone AF. Recently, it was proposed that congenital defects in the morphogenesis of the pulmonary vein myocardium are involved in genetic pathogenesis of lone AF. GATA4 is a cardiac transcription factor essentially involved in myocardial development. Mutations in GATA4 are associated with congenital cardiac malformations. To...
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