Article
GATA4 loss-of-function mutations in familial atrial fibrillation.
Clinica chimica acta; international journal of clinical chemistry - 18 Sept 2011
Yang Yi-Qing, Wang Mao-Ya, Zhang Xian-Ling, Tan Hong-Wei, Shi Hai-Feng, Jiang Wei-Feng, Wang Xin-Hua, Fang Wei-Yi, Liu Xu
Abstract excerpt
BACKGROUND: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major source of the substantially increased morbidity and mortality. Growing studies demonstrate that genetic defects play pivotal roles in a subgroup of AF. However, AF is a genetically heterogeneous disorder and the molecular basis of AF in a majority of cases remains unknown. METHODS: The whole coding region of the GATA4...
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