Article
Detection and putative effect of GATA4 gene variants in patients with congenital cardiac septal defects.
Cellular and molecular biology (Noisy-le-Grand, France) - 20 Mar 2016
Al-Azzouny M A, El Ruby M O, Issa H A, Behiry E G, Elsayed N R, Fayez A G
Abstract excerpt
The zinc finger transcription factor GATA4, located on chromosome 8p23.1-p22, has been implicated as a critical regulator of cardiac development during embryogenesis. Mutations of GATA4 appear to be responsible for some cardiac septal defects. The aim of this work was to screen for mutations in the GATA4 gene in sample of Egyptian patients affected by isolated and non-isolated cardiac septal defects. We examined...
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