Article
Gain-of-function mutations in GATA6 lead to atrial fibrillation.
Heart rhythm - 1 Feb 2017
Tucker Nathan R, Mahida Saagar, Ye Jiangchuan, Abraham Elizabeth J, Mina Julie A, Parsons Victoria A, McLellan Michael A, Shea Marisa A, Hanley Alan, Benjamin Emelia J, Milan David J, Lin Honghuang, Ellinor Patrick T
Abstract excerpt
BACKGROUND: The genetic basis of atrial fibrillation (AF) and congenital heart disease remains incompletely understood. OBJECTIVE: We sought to determine the causative mutation in a family with AF, atrial septal defects, and ventricular septal defects. METHODS: We evaluated a pedigree with 16 family members, 1 with an atrial septal defect, 1 with a ventricular septal defect, and 3 with AF; we performed whole...
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