Article
Gene set-level network analysis using a toxicogenomics database.
Genomics - 1 Jul 2010
Kiyosawa Naoki, Manabe Sunao, Sanbuissho Atsushi, Yamoto Takashi
Abstract excerpt
Toxicogenomics data sets on rat livers covering 118 compounds were subjected to inference of a gene set-level, not individual gene-level, network structure. Expression changing levels for 58 gene sets was used for network inference with a Gaussian graphical model algorithm. The established network contained reasonable relationships, such as ones between the blood glucose level and glycolysis-related genes or the...
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