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Article

Human immortalized chondrocytes carrying heterozygous FGFR3 mutations: an in vitro model to study chondrodysplasias.

FEBS letters - 12 Jun 2007

Benoist-Lasselin Catherine, Gibbs Linda, Heuertz Solange, Odent Thierry, Munnich Arnold, Legeai-Mallet Laurence

Abstract excerpt

Achondroplasia and thanatophoric dysplasia are human chondrodysplasias caused by mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. We have developed an immortalized human chondrocyte culture model to study the regulation of chondrocyte functions. One control and eight mutant chondrocytic lines expressing different FGFR3 heterozygous mutations were obtained. FGFR3 signaling pathways were modified...

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Source

Identifiers

PMID: 17507011
DOI: 10.1016/j.febslet.2007.04.079

Genes

FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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