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Article

Modelling the human immune response mechanisms to mycobacterium tuberculosis infection in the lungs

1 Jan 2006

Abstract excerpt

This work elaborates on the effects of cytotoxic lymphocytes (CTLs) and other immune mechanisms in determining whether a TB-infected individual will develop active or latent TB. It answers one intriguing question: why do individuals infected with Mycobacterium tuberculosis (Mtb) experience different clinical outcomes? In addressing this question, we have developed a model that captures the effects of CTLs and the...

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Identifiers

PMID: 20361838
DOI: 10.3934/mbe.2006.3.661

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