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Article

Evidence for a role of epithelial mesenchymal transition during pathogenesis of fistulae in Crohnʼs disease

14 Jul 2008

Abstract excerpt

BACKGROUND: The pathogenesis of fistulae in Crohn's disease (CD) patients is barely understood. We recently showed that more than two-thirds of CD fistulae are covered with flat, mesenchymal-like cells (transitional cells [TC]) forming a patchy basement membrane. Epithelial-to-mesenchymal transition (EMT) is a process of reprogramming epithelial cells, allowing them to migrate more effectively and giving...

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PMID: 18626977
DOI: 10.1002/ibd.20590

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