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Article

A functional variant within the MMP3 gene does not associate with human range of motion.

Journal of science and medicine in sport - 1 Nov 2010

Posthumus Michael, Raleigh Stuart M, Ribbans William J, Schwellnus Martin P, Collins Malcolm

Abstract excerpt

A recent heritability study has demonstrated that human range of motion (ROM) has a substantial genetic component. Furthermore, the COL5A1BstUI RFLP has now been identified as the first gene variant to be associated with human ROM. Interestingly, this variant is known to interact with a functional variant within the MMP3 gene (rs679620) to increase risk of Achilles tendinopathy. We sought to determine whether the...

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Source

Identifiers

PMID: 20359947
DOI: 10.1016/j.jsams.2010.01.006

Genes

MMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A functional variant within the MMP3 gene does not associate with human range of motion.PMID 20359947Read ↗

No association between COL3A1, COL6A1 or COL12A1 gene variants and range of motion.Semantic proximity Read ↗

The <i>COL5A1</i> genotype is associated with range of motion measurementsSemantic proximity Read ↗

Variants within the MMP3 gene and patellar tendon properties in vivo in an asymptomatic population.Semantic proximity Read ↗

Range of motion measurements diverge with increasing age for COL5A1 genotypes.Semantic proximity Read ↗

The MMP3 gene in musculoskeletal soft tissue injury risk profiling: A study in two independent sample groups.Semantic proximity Read ↗

Variants within the MMP3 gene are associated with Achilles tendinopathy: possible interaction with the COL5A1 gene.Semantic proximity Read ↗

Lack of association of matrix metalloproteinase 3 (MMP3) genotypes with ankylosing spondylitis susceptibility and severity.Semantic proximity Read ↗

Variants within the COMP and THBS2 genes are not associated with Achilles tendinopathy in a case-control study of South African and Australian populations.Semantic proximity Read ↗

COL5A1 rs12722 polymorphism is not associated with passive muscle stiffness and sports-related muscle injury in Japanese athletes.Semantic proximity Read ↗

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