Article
Modulation of mismatch repair and genomic stability by miR-155.
Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2010
Valeri Nicola, Gasparini Pierluigi, Fabbri Muller, Braconi Chiara, Veronese Angelo, Lovat Francesca, Adair Brett, Vannini Ivan, Fanini Francesca, Bottoni Arianna, Costinean Stefan, Sandhu Sukhinder K, Nuovo Gerard J, Alder Hansjuerg, Gafa Roberta, Calore Federica, Ferracin Manuela, Lanza Giovanni, Volinia Stefano, Negrini Massimo, McIlhatton Michael A, Amadori Dino, Fishel Richard, Croce Carlo M
Abstract excerpt
Inactivation of mismatch repair (MMR) is the cause of the common cancer predisposition disorder Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), as well as 10-40% of sporadic colorectal, endometrial, ovarian, gastric, and urothelial cancers. Elevated mutation rates (mutator phenotype), including simple repeat instability [microsatellite instability (MSI)] are a signature of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.