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Article

Biochemical conservation and evolution of germacrene A oxidase in asteraceae.

The Journal of biological chemistry - 28 May 2010

Nguyen Don Trinh, Göpfert Jens Christian, Ikezawa Nobuhiro, Macnevin Gillian, Kathiresan Meena, Conrad Jürgen, Spring Otmar, Ro Dae-Kyun

Abstract excerpt

Sesquiterpene lactones are characteristic natural products in Asteraceae, which constitutes approximately 8% of all plant species. Despite their physiological and pharmaceutical importance, the biochemistry and evolution of sesquiterpene lactones remain unexplored. Here we show that germacrene A oxidase (GAO), evolutionarily conserved in all major subfamilies of Asteraceae, catalyzes three consecutive oxidations...

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Identifiers

PMID: 20351109
DOI: 10.1074/jbc.M110.111757
PMCID: PMC2878029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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