Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired Mitochondrial Biogenesis Precedes Heart Failure in Right Ventricular Hypertrophy in Congenital Heart Disease

13 Aug 2011

Abstract excerpt

BACKGROUND: The outcome of the surgical repair in congenital heart disease correlates with the degree of myocardial damage. In this study, we determined whether mitochondrial DNA depletion is a sensitive marker of right ventricular (RV) damage and whether impaired mitochondrial DNA (mtDNA) replication contributes to the transition from compensated hypertrophy to failure. METHODS AND RESULTS: RV samples obtained...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Congenital Heart Disease Studies
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21840936
DOI: 10.1161/circheartfailure.111.961474

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired Mitochondrial Biogenesis Precedes Heart Failure in Right Ventricular Hypertrophy in Congenital Heart DiseasePMID 21840936Read ↗

Impaired mitochondrial biogenesis is a common feature to myocardial hypertrophy and end-stage ischemic heart failureSemantic proximity Read ↗

Defective DNA Replication Impairs Mitochondrial Biogenesis In Human Failing HeartsSemantic proximity Read ↗

Divergent Mitochondrial Biogenesis Responses in Human CardiomyopathySemantic proximity Read ↗

Transcriptional Signatures of the Right Ventricle in End-Stage Heart FailureSemantic proximity Read ↗

Dynamic microRNA expression during the transition from right ventricular hypertrophy to failureSemantic proximity Read ↗

Right ventricular phenotype, function, and failure: a journey from evolution to clinics.Semantic proximity Read ↗

Cardiac mitochondrial dysfunction and DNA depletion in children with hypertrophic cardiomyopathy.Semantic proximity Read ↗

Age-related decline in stress responses of human myocardium may not be explained by changes in mtDNA.Semantic proximity Read ↗

Reduction in activity and abundance of mitochondrial electron transport chain supercomplexes in pulmonary hypertension-induced right ventricular dysfunctionSemantic proximity Read ↗

Chronic carvedilol treatment partially reverses the right ventricular failure transcriptional profile in experimental pulmonary hypertensionSemantic proximity Read ↗

Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart.Semantic proximity Read ↗

Mitochondrial Structural Abnormalities and Cardiac Reverse Remodeling in Patients With Systolic DysfunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.